Optical Detectors

Chiral separation has become one of the most important application areas in HPLC. The increasing demand for chiral chromatography in various fields, such as drug analysis, drug discovery, biochemical analysis, natural product analysis, organic synthesis, etc. have resulted in a parallel demand for better chiral separation and detection technology. Recent advances in chiral column technology are boosting the use of chiral chromatography in more and more laboratories; however, advances in chiral detection technology have only recently met the demands required in terms of sensitivity and selectivity.

Recently, particularly in the pharmaceutical industry, such optical isomers have to be separated, detected and fractionated in order to investigate the biological activity of each. An HPLC system including a chiral separation column and a chiral detector is essential for such research work.

We at JASCO, a world leader in chiro-optical spectroscopy as well as HPLC instrumentation have developed such chiral detectors for HPLC to meet the demand.

CD-2095 Circular Dichroism Chiral Detector
The world's first Circular Dichroism based detector for chiral chromatography

The CD-2095 has been developed as an innovative CD (Circular Dichroism) detector, using the same technology applied in conventional CD spectropolarimeters, but optimized to meet HPLC requirements. It can simultaneously determine both CD and UV absorption of the sample in the same cell for direct determination of optical purity.

• Simultaneous acquisition of CD, UV and g-factor signals
• Direct determination of optical isomer separation and purity
• Spectral scanning capability
• Up to 100× greater sensitivity than ORD
• Wide range of applications, including drug analysis, drug discovery, biochemical analysis, natural product analysis, organic synthesis, etc.

Click here to view the CD-2095 Circular Dichroism chiral detector specifications.

OR-2090 Chiral Detector
The OR-2090 is specifically designed for the detection of optically active compounds such as amino acids, sugars and terpenes.

JASCO Model OR-2090 Chiral Detector has been designed for the detection of optically active compounds such as amino acids, sugars, terpenes, and other compounds containing an asymmetric carbon. In industry, these compounds are widely used as original materials for pharmaceuticals, biochemicals, agricochemicals, cosmetics, foods, and beverages. It is well known that optical isomers of these compounds often exhibit totally different biological activity. One offers a favorable effect to human body while the other can offer a dangerous or unknown effect.

• Low noise and drift
• Hg/Xe lamp to cover the wavelength range from UV to visible
• Patented flow cell for low dispersion
• Auto-aligning flow cell is easily removed for cleaning
• Artifact free

Click here to view the OR-2090 Chiral detector specifications.

CL-2027 Chemiluminescence Detector
Detection of optically active compounds

The Model CL-2027 chemiluminescence detector is equipped with JASCO's uniquely designed coiled PTFE tube flow cell placed immediately next to a highly sensitive end-on PMT. The flow cell, combined with digital filtering allows the CL-2027 to boast the highest S/N ratio in its class. The CL-2027 satisfies the need for optimum chemiluminescence detection limits as demand increases for detection of trace amounts of lipids, nucleotides, nitrogen oxides (NOx), and catecholamines. 

• Equipped with a low dispersion flow cell
• Sensitive detection of lipids, nucleotides, nitrogen oxides (NOX) and catecholamines

Click here to view the CL-2027 Chemiluminescence detector specifications.

RI-2031 Refractive Index Detector
High-sensitivity detection with a prism flow cell

The JASCO Model RI-2031 RI detector is a microcomputer based Differential Refractometer which combines a high-quality optical system with advanced electronics and microcomputer control/programming capabilities. The RI-2031 is the latest addition to the new high-performance, easy-to-use and extremely compact LC-2000 Plus series HPLC modules.

• Analytical and semi-preparative flow rate to 50 ml/min
• Low noise, stable baseline
• Time programming for sensitivity range and reference cell purging
• Temperature stabilization from 10°C above ambient to 45°C

Click here to view the RI-2031 Refractive Index detector specifications.