JASCO SFC Systems
There are many reasons for choosing an SFC system for separations. Supercritical Fluid chromatography has often been cited as an ‘alternative’ to Normal Phase HPLC (NPLC), however it is much more than that – SFC is truly an orthogonal technique to Reverse Phase HPLC (RPLC) and offers a much greater capability than simple NPLC separations. Samples that can be separated by RPLC can often be separated by SFC and in many cases with better resolution, higher column loading and faster run times.
SFC has long been the method of choice for chiral separations, but with the large range (and growing rapidly) of stationary phases available – SFC is now becoming a powerful tool for achiral separations, both analytically and for sample prep.
Find out more about the range of SFC systems
Benefits of using SFC Systems for separation
- Greater solubility and lower viscosity than liquid phase HPLC leading to rapid column equilibration, faster separations and higher productivity.
- Applicable to a wide range of molecular structures with a wide range of polarities from strongly hydrophobic to strongly hydrophilic.
- Simple separation solvents - generally CO2 with alcoholic modifiers, which are much greener than other solvents generally used in NPLC and RPLC.
- Dramatic reduction in solvent costs for both purchase and disposal.
- SFC scales-up from analytical to preparative with ease, so method development for high quality chiral and achiral sample purification with low solvent contamination is completely straightforward.
The JASCO SFC System Advantage
- JASCO SFC and SFE systems have been continually optimized and refined over the last 25 years to provide reliable, worry-free performance for a wide variety of applications.
- The patented high-speed switching back-pressure regulator ensures that a constant back pressure is maintained at all times, regardless of the flow rate with virtually no hysteresis. Very low dead volume (<10 μL) which prevents fractions from remixing. It also prevents precipitation build-up in the flow line.
- Wide range of detectors – UV, Diode Array (real-time collection of 3-D spectra and chromatograms), and the CD-2095 the only chiral detector for SFC. Non-optical detectors include FID, ELSD and Mass-spec.
- The analytical SFC system can be easily switched for use with HPLC applications.
- A truly modular system – construct your system from a simple system to a complex multi-instrument system using a wide range of high quality instruments.
- JASCO SFC systems are compatible with most Mass Spectrometers and offer direct control in both Thermo Xcalibur and Sciex Analyst software.
- JASCO provides professional, fast and courteous support on all of our products. We have service centers strategically located throughout the U.S. to ensure the highest level of customer satisfaction. Our scheduled and on-site training classes are available for advanced application training.
- JASCO offers multiple configurations, please contact us to discuss your requirements in detail.