The SF-4000 series of SFC systems are used in both chiral and achiral chromatography, from simple analytical separations for routine analyisis and method development through to preparative systems at scales using from 1cm to 3cm ID columns.
The use of supercritical fluids offers a green alternative to traditional HPLC with the use of CO2 in place of organic solvents. This reduction offers cost, health, and safety benefits, as well as faster, cleaner sample recovery during material purification. Other advantages of supercritical fluids include the liquid-like densities, for higher solubility and increased column loading. The low viscosity and highly diffusion lead to faster separations and faster extractions.
SFC has long been the method of choice for chiral separations, but with the large range (and growing rapidly) of column phases available – SFC is now becoming a powerful tool for achiral separations, both analytically and for sample prep.
JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in the new SFC-4000 series being even more user friendly, robust and powerful.
The BP-4340 high-speed dynamic back-pressure regulator ensures that an accurate and constant back pressure (typically within a few psi), regardless of the flow rate and with virtually no hysteresis. The extremely low dead volume prevents fractions from remixing and prevents precipitation build-up in the flow line.
Dual wavelength UV-visible, PDA and the CD-4095 the only chiral detector suitable for SFC. Non-optical detectors include FID, ELSD and single-quad mass-spec.
All 4000 series SFC systems can be used for HPLC, simply switch off the cooling and BPR.
The basic system for each scale can be adapted to suit your application. From modifier selection to column heater type to detector combinations.
JASCO SFC systems are compatible with most Mass Spectrometers and offer direct control with both Advion CMS and Sciex Analyst.
The three individual platforms for analytical, semi-prep and preparative scales can be customized to suit all applications, just let us know what you are planning. We also provide individual modules with serial communications with a simple protocol.
Greater solubility and lower viscosity than liquid phase HPLC leading to rapid column equilibration, faster separations and higher productivity.
Applicable to a wide range of molecular structures with a wide range of polarities from strongly hydrophobic to strongly hydrophilic.
SFC uses simple separation solvents, generally CO2 with alcoholic modifiers, which are much greener than other solvents generally used in NPLC and RPLC.
Dramatic reduction in solvent costs for both purchase and disposal.
SFC scales-up from analytical to preparative with ease, so method development for high quality chiral and achiral sample purification with low solvent contamination is completely straightforward.
The JASCO SF-4000 integrated Analytical SFC system has been developed for routine separation to method development
SP-4000 Semi-prep hybrid SFC system crosses the divide between analytical and semi-prep SFC
4000 series Supercritical fluid extraction (SFE) for analytical to liter scale material extraction.