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Application Note:
Thermal Denaturation of Hen-egg Lysozyme with Concurrent CD and Fluorescence Detection

Application Note:
CD detection of Myoglobin Structure During an Automated pH Titration

Download the "Pioneering in Modern Protein Science" PDF brochure (200 Kbytes)

Download the "Rapid Kinetic (Protein Refolding) Monitored Using Stopped-flow/CD/Fluorescence" PDF leaflet (100 Kbytes)

Download a PDF J-815 Circular Dichroism System Catalog (312 KB)

	Measurement from 163-1100 nm with highesft signal to noise ever achieved
	New auto-response measurement optimizes instrument response to scan speed and signal
	Auto-scale mode for data acquisition
	Remarkable stability eliminates need for frequent calibration
	Extreme low stray light (0.0003%) assures accurate, reproducible data in Far UV
	Compact, air-cooled design
	Spectra Manager II and Spectra Manager CFR software for Windows XP Pro

The J-815 is the latest introduction to the long line of Circular Dichroism instrumentation from JASCO. Unparalleled optical performance and optionally available measurement modes are combined in a manner to make the J-815 true "chiro-optical spectroscopy workbench".

Control by Spectra Manager™ II or Spectra Manager™ CFR

Spectra Manager offers the most flexible and easy-to-use control interface ever applied to a research spectrometer. Complete data acquisition and analysis are performed in the same common software program employed by our range of instrumentation. Power functions related specifically to CD Spectroscopy are integrated seamlessly into the package. Macro mode allows complicated experiments with control of measurement mode, temperature and accessories to be quickly stored and executed in a totally automated mode. Extended macros allow data to be processed and printed in custom report formats. A second version of the software Spectra Manager CFR is available for FDA regulated industries that require data integrity and electronic signature features in order comply with FDA 21CFR11 mandates.

Measurement Modes:

Standard
	Circular Dichroism/UV/VIS absorbance
Optional
	Linear Dichroism		Stopped-Flow Absorbance
	Optical Rotatory Dispersion		Stopped-Flow Fluorescence
	Total Fluorescence		Chiral HPLC Detection
	Scanning EM Fluorescence		Magnetic CD
	Fluorescence Detected CD		Near Infrared CD
	Stopped-Flow CD		Oriented CD

Want to squeeze as much information as possible from your precious sample? Why not outfit your CD instrument to do several jobs for you! The J-815 configured with the PFD-452S Peltier cell holder, FMO-427 EM Monochromator, Titrator and Macro software will enable acquisition of CD data simultaneous with Fluorescence data during thermal melts and chemical denaturation studies.

Macro software can be set up to use different wavelengths for CD absorbance (for example 208 and 222 nm) and Fluorescence excitation (example 280 nm) and also acquire spectral scans of both CD and Fluorescence at pre-set temperature intervals. A single automated experiment could produce enough data to keep you busy with productive analysis instead of spending your time isolating more samples.

Spectra Manager ™ II and Spectra Manager ™ CFR

JASCO is the first instrument manufacturer to offer a powerful 32 bit Windows® software platform for control of it's full range of spectroscopy instrumentation as well as complete analysis and display of any kind of spectral data. Spectra Manager is an innovative approach to a cross-platform package setting a new standard for ease of use and allowing users to work seamlessly between several different types of instrumentation. Spectra Manager CFR includes all the features required to comply with FDA 21CFR11 requirements.

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